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Tris(furan-2-yl)phosphane → 2,4-Diamino-6-methyl-5-[1-fluoro-3-methyl-3-(4-chlorophenyl)-1-butenyl]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tris(furan-2-yl)phosphane | HCID 521585 | — |
| 反応物 | 5-Iodo-6-methylpyrimidine-2,4-diamine | HCID 15855792 | — |
| 反応物 | 1-Fluoro-3-(4-chlorophenyl)-3-methyl-1-tributylstannyl-1-butene | HCID 67632345 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2,4-Diamino-6-methyl-5-[1-fluoro-3-methyl-3-(4-chlorophenyl)-1-butenyl]pyrimidine | HCID 54232355 | — |
反応手順
This compound is prepared in a manner analogous to that of Step E of Example 4, using 1.2 grams (0.0048 mole) of 2,4-diamino-5-iodo-6-methylpyrimidine, 2.3 grams (0.0048 mole) of 1-fluoro-3-(4-chlorophenyl)-3-methyl-1-tributylstannyl-1-butene, 0.04 gram of tri-2-furylphosphine, 0.04 gram of tris(dibenzylidineacetone)dipalladium(0) in about 30 mL of N,N-dimethylformamide, yielding 2,4-diamino-6-methyl-5-[1-fluoro-3-methyl-3-(4-chlorophenyl)-1-butenyl]pyrimidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05622954 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-f7e0132fef5c4ba29f07494aaaf13849 |
| 出典メモ | uspto-grants-1997_04 |