1-Isopropyl-1H-pyrrole-2-carbaldehyde → 1-n-Propylpyrrole-2-carbonitrile

HRID 542859ノート

反応式

HRID 542859 の反応式
[CH2:1]([N:4]1[CH:8]=[CH:7][CH:6]=[C:5]1[CH:9]=O)[CH2:2][CH3:3].C([N:14]1C=CC=C1C=O)(C)C>ClCCl>[CH2:1]([N:4]1[CH:8]=[CH:7][CH:6]=[C:5]1[C:9]#[N:14])[CH2:2][CH3:3]

参加物

4

反応物 2

HCID 31559701-Isopropyl-1H-pyrrole-2-carbaldehydeHCID 230047561-Propyl-1H-pyrrole-2-carbaldehyde

生成物 1

HCID 135893091-n-Propylpyrrole-2-carbonitrile収率 45%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In the same manner as described in Reference Example 2 (1) except that 1-n-propylpyrrole-2-carbaldehyde (prepared in the same manner as described in Can. J. Chem., 55, 4112, 1977, b.p. 72°-75°C./5 mmHg) (8.2 g, 60 mmole) is used instead of 1-isopropylpyrrole-2-carbaldehyde and further the product is isolated by silica gel column chromatography (solvent: dichloromethane) instead of distillation under reducted pressure, there is obtained 1-n-propylpyrrole-2-carbonitrile (3.6 g, yield: 45%).

後処理

  1. customprepared in the same manner

出典と根拠

ORDレコード
ord-8b4210d2ec844bae87181a9120b2c905
出典データセット
uspto-grants-1987_04
特許番号
US04659726

反応ノート

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