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2-(Trifluoromethyl)aniline → 1,1-Bis(4-chlorophenylsulphonyl)-2-[2-(trifluoromethyl)anilino]ethene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Trifluoromethyl)aniline | HCID 6922 | — |
| 反応物 | 1-Chloro-4-({1-[(4-chlorophenyl)sulfonyl]-2-ethoxyvinyl}sulfonyl)benzene | HCID 3371370 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 1,1-Bis(4-chlorophenylsulphonyl)-2-[2-(trifluoromethyl)anilino]ethene | HCID 20207509 | 50.1% |
反応手順
A solution of 1,1-bis(4-chlorophenylsulphonyl)-2-ethoxyethene (1.26 g) and 2-(trifluoromethyl)aniline (0.48 g) in dimethylacetamide (20 ml) was heated at reflux for 2 hours, and then it was cooled and poured onto ice (50 g). The resulting white precipitate was filtered off, washed with water and recrystallised from ethanol, to give 1,1-bis(4-chlorophenylsulphonyl)-2-[2-(trifluoromethyl)anilino]ethene (0.8 g), m.p. 169°-171° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04659727 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-603f45c2fba84f72880705f9baeb8a82 |
| 出典メモ | uspto-grants-1987_04 |