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Ethyl cyanoacetate → 4-Amino-alpha-cyano-3,5-dimethoxy-cinnamic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl cyanoacetate | HCID 7764 | — |
| 反応物 | 4-Amino-3,5-dimethoxybenzaldehyde | HCID 20042963 | — |
| 触媒 | Piperidine | HCID 8082 | — |
| 生成物 | 4-Amino-alpha-cyano-3,5-dimethoxy-cinnamic acid ethyl ester | HCID 54272862 | — |
反応手順
A mixture of 18.1 g. of 4-amino-3,5-dimethoxy-benzaldehyde, 11.3 g. of cyanoacetic acid ethyl ester and 3 drops of piperidine was heated at 120° C. for 1 hour in an open vessel, whereby the formed water evaporated. The residue was recrystallized from ethyl acetate/petroleum ether and there was obtained 4-amino-α-cyano-3,5-dimethoxy-cinnamic acid ethyl ester having a melting point of 134°-136° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04659818 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-f25a0d0cbacc46d3b4d3b5f860565648 |
| 出典メモ | uspto-grants-1987_04 |