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Hydrochloric Acid → 6-Methyl-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Benzenediazonium chloride | HCID 60992 | — |
| 反応物 | 2H-Pyran-2-one | HCID 68154 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-Methyl-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxylic acid | HCID 2784470 | — |
反応手順
In a separate flask; 9.08 g of aniline is mixed with 37.5 ml of concentrated hydrochloric acid and 47 ml of water. The resulting solution is maintained at about 5° to 10° and a solution of 7.13 g of sodium nitrite in 24 ml of water is added. The resulting solution of phenyldiazonium chloride is added dropwise to the stirred pyrone solution, while maintaining a temperature of about 5° to 10°. The pH is maintained at about 8 to 9 by the addition of small amounts of sodium hydroxide solution.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04661145 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-3ab5e60f47054849a6871ffbb2463730 |
| 出典メモ | uspto-grants-1987_04 |