Acetic Anhydride → N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]acetamide
反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=2)[N:6]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([N+:13]([O-:15])=[O:14])=[CH:11][CH:12]=2)[N:6]=1)(=[O:18])[CH3:17]参加物
3
実験手順
30 g of 2-amino-4-(4'-nitrophenyl)-1,3-thiazole (prepared in accordance with J. Chem. Soc. 1959, (2365) and 100 ml of acetic anhydride are heated for 3 hours at 140° C. Excess acetic anhydride is removed by vacuum distillation and the residue is treated with 500 ml of warm water, filtered, washed, and dried to constant weight, affording 34 g of 2-acetamido-4-(4'-nitrophenyl)-1,3-thiazole.
後処理
- customExcess acetic anhydride is removed by vacuum distillation
- additionthe residue is treated with 500 ml of warm water
- filtrationfiltered
- washwashed
- customdried to constant weight
出典と根拠
- ORDレコード
- ord-59a9df87483c43a7b2d32c0a90ec94a6
- 出典データセット
- uspto-grants-1987_04
- 特許番号
- US04661437
反応ノート
読み込み中…