Norpyridostigmine → HCID 20205836、化合物

HRID 543158

反応式

HRID 543158 の反応式
[CH3:1][N:2]([CH3:12])[C:3]([O:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)=[O:4].[Cl:13][CH2:14][O:15][C:16](=[O:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>>[Cl-:13].[CH3:1][N:2]([CH3:12])[C:3]([O:5][C:6]1[CH:7]=[N+:8]([CH2:14][O:15][C:16](=[O:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH:9]=[CH:10][CH:11]=1)=[O:4]

参加物

3

反応物 2

HCID 98821NorpyridostigmineHCID 525229Chloromethyl hexanoate

生成物 1

HCID 20205836HCID 20205836、化合物収率 80.2%

実験手順

3-Dimethylcarbamoyloxypyridine (1.66 g) and chloromethylhexanoate (2.0 g) were heated to 90° C. with stirring for 3 hours. The reaction mixture was treated in a similar manner as described in Example 1 to give 2.65 g of 3-(dimethylcarbamoyloxy)-1-(hexanoyloxymethyl)-pyridinium chloride as colorless powdery crystals. It was impossible to precisely measure the melting point because of high hygroscopicity. The structure was determined by N.M.R.

後処理

  1. additionThe reaction mixture was treated in a similar manner

出典と根拠

ORDレコード
ord-390da6494e7b419eac2dc5ef8c661421
出典データセット
uspto-grants-1987_04
特許番号
US04661502

関連ノート

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