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Chloromethyl benzoate → 3-(Dimethylcarbamoyloxy)-1-(phenylcarbonyloxymethyl)pyridinium chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloromethyl benzoate | HCID 79257 | — |
| 反応物 | Norpyridostigmine | HCID 98821 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-(Dimethylcarbamoyloxy)-1-(phenylcarbonyloxymethyl)pyridinium chloride | HCID 13881954 | 85.2% |
反応手順
3-Dimethylcarbamoyloxypyridine (4.98 g) and chloromethylbenzoate (5.13 g) were heated to 70° C. with stirring for 4 hrs. The hot reaction mixture was poured into 100 ml of diethyl ether with vigorous stirring. The precipitated solids were filtered off and washed twice with anhydrous diethyl ether (100 ml×2). Recrystallization from acetone gave 8.6 g of 3-(dimethylcarbamoyloxy)-1-(phenylcarbonyloxymethyl)pyridinium chloride as prisms, m.p. 175°-176° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04661502 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-4fe42735981d4326ac1d16bf7b548e47 |
| 出典メモ | uspto-grants-1987_04 |