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Triethylamine → 1-{3-[4-(4-Chlorobenzyl)piperazin-1-yl]propyl}-3-n-octylurea dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Octyl isocyanate | HCID 76616 | — |
| 反応物 | 1-(3-Aminopropyl)-4-(4-chlorobenzyl)piperazine trihydrochloride | HCID 20205739 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-{3-[4-(4-Chlorobenzyl)piperazin-1-yl]propyl}-3-n-octylurea dihydrochloride | HCID 13606677 | 125% |
反応手順
The procedure described in Example 3 was followed, using 1-(3-aminopropyl)-4-(4-chlorobenzyl)piperazine trihydrochloride (3.77 g; 10 mmole), tetrahydrofuran (50 ml), triethylamine (4.2 ml; 30 mmole) and n-octyl isocyanate (1.55 g; 10 mmole). Recrystallization from methanol/ethanol/water provided the title compound (3.1 g; 62% yield) as colorless crystals, m.p. 229°-230° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04661481 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-8f74e7ddcff4460d9fc58d202e265dd9 |
| 出典メモ | uspto-grants-1987_04 |