5-Bromopentanenitrile → HCID 178439679、化合物

HRID 543222ノート

反応式

HRID 543222 の反応式
[OH:1][C:2]1[C:15]([CH2:16][CH2:17][CH3:18])=[C:14]([OH:19])[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].Br[CH2:21][CH2:22][CH2:23][CH2:24][C:25]#[N:26].[NH:27]1C=N[N:29]=[N:28]1>>[C:4]([C:3]1[CH:12]=[CH:13][C:14]([O:19][CH2:21][CH2:22][CH2:23][CH2:24][C:25]2[NH:26][N:29]=[N:28][N:27]=2)=[C:15]([CH2:16][CH2:17][CH3:18])[C:2]=1[OH:1])(=[O:5])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 3

HCID 794355-BromopentanenitrileHCID 13019373(2,4-Dihydroxy-3-propylphenyl)(phenyl)methanoneHCID 178418441HCID 178418441、化合物

生成物 1

HCID 178439679HCID 178439679、化合物

実験手順

The title compound was prepared by first reacting 7.68 g. of 2,4-dihydroxy-3-propylbenzophenone with 4.86 g. of 5-bromovaleronitrile according to the procedure in Example 21. The reaction afforded 8.2 g. of the nitrile intermediate of the title compound. This nitrile intermediate was then converted to the tetrazole following the procedure of Example 8 giving 1.2 g. of the title compound, m.p. about 114°-115° C.

後処理

  1. customThe title compound was prepared
  2. customThe reaction afforded 8.2 g

出典と根拠

ORDレコード
ord-02fc2c6a40c64c2a986cb49677145d01
出典データセット
uspto-grants-1987_04
特許番号
US04661505

反応ノート

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