Benzenamine, 3,5-bis(trifluoromethyl)- → Cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclobutane carboxylic acid

反応式

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)[NH2:6].[CH:16]12[C:23](=[O:24])[O:22][C:20](=[O:21])[CH:17]1[CH2:18][CH2:19]2>>[F:1][C:2]([F:14])([F:15])[C:3]1[CH:4]=[C:5]([NH:6][C:23]([C@H:16]2[CH2:19][CH2:18][C@H:17]2[C:20]([OH:22])=[O:21])=[O:24])[CH:7]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:9]=1

参加物

反応物 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-

HCID 1382613-Oxabicyclo(3.2.0)heptane-2,4-dione

生成物 1

HCID 18607497Cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclobutane carboxylic acid

実験手順

From 2.3 g of 3,5-bistrifluoromethyl aniline and 1.1 g of cyclobutane-1,2-dicarboxylic anhydride used as starting materials, the title compound was obtained in the same manner as in Example 1.

出典と根拠

ORDレコード: ord-8c65be023f484ca0861d6823bc2f684c
出典データセット: uspto-grants-1987_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04661630

反応ノート

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