Bromine → 3,3-Bisfluoromethyl-1-bromo-butan-2-one

HRID 543366ノート

反応式

HRID 543366 の反応式
[Br:1]Br.[F:3][CH2:4][C:5]([CH2:10][F:11])([CH3:9])[C:6](=[O:8])[CH3:7]>C(Cl)Cl>[F:3][CH2:4][C:5]([CH2:10][F:11])([CH3:9])[C:6](=[O:8])[CH2:7][Br:1]

参加物

4

反応物 2

HCID 24408BromineHCID 130194334-Fluoro-3-(fluoromethyl)-3-methylbutan-2-one

生成物 1

HCID 130194343,3-Bisfluoromethyl-1-bromo-butan-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

51 ml (1 mol) of bromine were added dropwise to 136 g (1 mol) of 3,3-bisfluoromethylbutane-2-one in 700 ml of methylene chloride such that decoloration was continuous. The solvent was then distilled off under a water pump vacuum. An almost quantitative yield of crude 3,3-bisfluoromethyl-1-bromo-butan-2-one was obtained as an oil, which could be further reacted directly.

後処理

  1. distillationThe solvent was then distilled off under a water pump vacuum

出典と根拠

ORDレコード
ord-f771d13f0090404cafd1ea390e83f465
出典データセット
uspto-grants-1987_04
特許番号
US04661640

反応ノート

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