化工社化工社 化学情報印刷レポート · 研究参考用
Water → 2-(2-Iodo-5-methoxyphenyl)acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | (3-Methoxyphenyl)acetic acid | HCID 15719 | — |
| 反応物 | Iodine chloride | HCID 24640 | — |
| 触媒 | Iodine | HCID 807 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-(2-Iodo-5-methoxyphenyl)acetic acid | HCID 820071 | 65% |
反応手順
A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04661635 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-b4f7f8a97a8e42fb9576438e9b94f03a |
| 出典メモ | uspto-grants-1987_04 |