N-[4-chloro-2-nitro-6-(trifluoromethyl)phenyl]acetamide → 2-Amino-5-chloro-3-nitrobenzotrifluoride

HRID 54353ノート

反応式

HRID 54353 の反応式
C([NH:4][C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([Cl:14])=[CH:7][C:6]=1[C:15]([F:18])([F:17])[F:16])(=O)C>Cl>[NH2:4][C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([Cl:14])=[CH:7][C:6]=1[C:15]([F:18])([F:16])[F:17]

参加物

3

反応物 1

HCID 10564882N-[4-chloro-2-nitro-6-(trifluoromethyl)phenyl]acetamide

生成物 1

HCID 27376442-Amino-5-chloro-3-nitrobenzotrifluoride収率 83%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A mixture of 2-acetamido-5-chloro-3-nitrobenzotrifluoride (354 mg, 1.252 mmol) in concentrated HCl (3 mL) was refluxed overnight, and it was extracted by ethyl acetate (2×3 mL). The extract was dried (Mg2SO4) and evaporated to give 250 mg (83%) of 2-amino-5-chloro-3-nitrobenzotrifluoride. 1H NMR (CDCl3): δ6.663 (s, 2H), 7.717 (s, 1H), 8.360 (s, 1H).

後処理

  1. temperaturewas refluxed overnight
  2. extractionit was extracted by ethyl acetate (2×3 mL)
  3. dry with materialThe extract was dried (Mg2SO4)
  4. customevaporated

出典と根拠

ORDレコード
ord-4a97e5e72e6a4a5c9ec0aa4a4cd94f5f
出典データセット
uspto-grants-1997_04
特許番号
US05622952

反応ノート

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