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Dacthal → 7-Amino-3-(2-morpholinocarbonylmethylthio-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dacthal | HCID 2943 | — |
| 反応物 | 7-Aminocephalosporanic acid | HCID 441328 | — |
| 反応物 | HCID 178521532 | HCID 178521532 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 7-Amino-3-(2-morpholinocarbonylmethylthio-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid | HCID 70462314 | — |
反応手順
While utilizing 0.680 g of 7-ACA, 0.900 g of 5-mercapto-2-morpholinocarbonylmethylthio-1,3,4-thiadiazole, 4.0 ml of acetonitrile and 2.70 g of DCPA, the procedure was carried out in accordance with Example 5, and there was obtained 1.02 g (83.3% of yield) of red brown powder of 7-amino-3-[(2-morpholinocarbonylmethylthio-1,3,4-thiadiazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04446318 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-291c79c7964c4fc395677d94a85f454b |
| 出典メモ | uspto-grants-1984_05 |