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Water → 7-Amino-3-(2-ethoxycarbonylmethylthio-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 7-Aminocephalosporanic acid | HCID 441328 | — |
| 反応物 | Diphosphoryl tetrachloride | HCID 4432411 | — |
| 反応物 | HCID 178473173 | HCID 178473173 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 7-Amino-3-(2-ethoxycarbonylmethylthio-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid | HCID 70463237 | 91.9% |
反応手順
The procedure was carried out in accordance with Example 22, while utilizing 1.36 g of 7-ACA, 0.36 g of water, 8.0 ml of acetonitrile, 1.54 g of 2-ethoxycarbonylmethylthio-5-mercapto-1,3,4-thiadiazole and 5.04 g of diphosphoryl tetrachloride, and there was obtained 2.06 g (91.8%) of 7-amino-3-(2-ethoxycarbonylmethylthio-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04446318 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-710dc0b2f3cc4c87918e449f412381c2 |
| 出典メモ | uspto-grants-1984_05 |