反応式
CC(O[CH2:5][C:6]1[CH2:15][S:14][C@@H:9]2[C@H:10]([NH2:13])[C:11](=[O:12])[N:8]2[C:7]=1[C:16]([OH:18])=[O:17])=O.O.[CH2:20]([O:22][C:23]([CH2:25][S:26][C:27]1[S:28][C:29]([SH:32])=[N:30][N:31]=1)=[O:24])[CH3:21].P(Cl)(Cl)(OP(Cl)(Cl)=O)=O>C(#N)C>[NH2:13][CH:10]1[C:11](=[O:12])[N:8]2[C:7]([C:16]([OH:18])=[O:17])=[C:6]([CH2:5][S:32][C:29]3[S:28][C:27]([S:26][CH2:25][C:23]([O:22][CH2:20][CH3:21])=[O:24])=[N:31][N:30]=3)[CH2:15][S:14][C@H:9]12参加物
6
実験手順
The procedure was carried out in accordance with Example 22, while utilizing 1.36 g of 7-ACA, 0.36 g of water, 8.0 ml of acetonitrile, 1.54 g of 2-ethoxycarbonylmethylthio-5-mercapto-1,3,4-thiadiazole and 5.04 g of diphosphoryl tetrachloride, and there was obtained 2.06 g (91.8%) of 7-amino-3-(2-ethoxycarbonylmethylthio-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid.
出典と根拠
- ORDレコード
- ord-710dc0b2f3cc4c87918e449f412381c2
- 出典データセット
- uspto-grants-1984_05
- 特許番号
- US04446318
関連ノート
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