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Sodium hydride → [2-[(3-Amino-2-pyridinyl)[3-(dimethylamino)propyl]amino]phenyl]phenylmethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-(Dimethylamino)propyl chloride hydrochloride | HCID 94308 | — |
| 反応物 | {2-[(3-Aminopyridin-2-yl)amino]phenyl}(phenyl)methanone | HCID 15586652 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [2-[(3-Amino-2-pyridinyl)[3-(dimethylamino)propyl]amino]phenyl]phenylmethanone | HCID 53769600 | — |
反応手順
To a stirred suspension of sodium hydride (in mineral oil) in anhydrous dimethylformamide, under nitrogen atmosphere was added, portionwise, [2-[(3-amino-2-pyridinyl)amino]phenyl]phenylmethanone. To the mixture was added 3-dimethylaminopropyl chloride hydrochloride to give a solution containing some of the title compound as indicated by chemical ionization mass spectrascopy analysis. With time, this cyclized spontaneously to the corresponding pyrido[2,3-b][1,4]benzodiazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04447361 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-e786f39c9cd84eb9b05f39092463ab08 |
| 出典メモ | uspto-grants-1984_05 |