Acetic Anhydride → Acetamide, N-(4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-

反応式

F[C:2](F)(F)[C:3]([NH:5][C:6]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14](C(=O)C(F)(F)F)=[CH:13][CH:12]=2)[N:7]=1)=[O:4].C(OC(=O)C)(=O)C>>[C:11]1([N:8]2[CH2:9][CH2:10][C:6]([NH:5][C:3](=[O:4])[CH3:2])=[N:7]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

反応物 2

HCID 7918Acetic Anhydride

HCID 15580703HCID 15580703、化合物

生成物 1

HCID 793093Acetamide, N-(4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-

実験手順

A 10.0 g. amount of 3-amino-1-phenyl-2-pyrazoline (prepared in Example 8) and 10.0 ml. of acetic anhydride are mixed together and allowed to stand at room temperature for one hour. The resulting solid is collected, dissolved in dichloromethane and passed through a short column of a hydrous magnesium silicate. The effluent is heated and hexane is added to crystallize 1.2 g. of the desired product as yellow prisms, m.p. 190°-191° C.

後処理

customThe resulting solid is collected
dissolutiondissolved in dichloromethane
temperatureThe effluent is heated
additionhexane is added
customto crystallize 1.2 g

出典と根拠

ORDレコード: ord-fec04c99ecac418591f684f81c1828a2
出典データセット: uspto-grants-1984_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04447442

反応ノート

読み込み中…

参加物