Formic Acid → HCID 15580711、化合物

HRID 543806ノート

反応式

HRID 543806 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][C:14](=[O:19])C(F)(F)F)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.C(O)=O.ClC1C=C(N2CC(C)C(NC=O)=N2)C=CC=1Cl>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][CH:14]=[O:19])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 284Formic AcidHCID 15580693HCID 15580693、化合物HCID 15580721HCID 15580721、化合物

生成物 1

HCID 15580711HCID 15580711、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 2.0 g. of 3-amino-1-(m-chlorophenyl)-2-pyrazoline (prepared in Example 10) and 10 ml. of a mixture of formic acid and acetic anhydride (Example 15) is allowed to stand at room temperature for 30 minutes. Then the solvent is evaporated in vacuo to give an oil. The oil is dissolved in dichloromethane and is columnized and recrystallized as described in Example 5 to give 1.32 g. of the desired product as pale yellow needles, m.p. 143°-145° C.

後処理

  1. additionA mixture of 2.0 g
  2. customThen the solvent is evaporated in vacuo
  3. customto give an oil
  4. customrecrystallized
  5. customto give 1.32 g

出典と根拠

ORDレコード
ord-5dd5727a5f334c8191869b11aeee9fef
出典データセット
uspto-grants-1984_05
特許番号
US04447442

反応ノート

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