化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 1,3-Dihydro-4-methyl-5-(2-phenylacetyl)-2H-imidazol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Phenylacetyl chloride | HCID 7679 | — |
| 反応物 | 1,3-dihydro-4-methyl-2H-imidazol-2-one | HCID 70935 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1,3-Dihydro-4-methyl-5-(2-phenylacetyl)-2H-imidazol-2-one | HCID 13072010 | — |
反応手順
To 26.6 g (0.2 mole) of aluminum chloride in 250 ml of dichloromethane is added 9.8 g (0.1 mole) of 1,3-dihydro-4-methyl-2H-imidazol-2-one and, dropwise, 16.9 g (0.11 mole) of phenylacetyl chloride. The mixture is stirred and heated to reflux for 5 hours. The mixture is cooled and 200 ml of 2N-hydrochloric acid is added dropwise. The resulting precipitate is collected, washed with water, and recrystallized for 50% aqueous ethanol to give the title compound, m.p. 239°-240° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04447619 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-794845417e3b415ca1d2a84de45cfb27 |
| 出典メモ | uspto-grants-1984_05 |