Acetic Anhydride → 3',5'-Bis(trifluoromethyl)acetanilide

反応式

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)[NH2:6].[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([NH:6][C:5]1[CH:4]=[C:3]([C:2]([F:14])([F:15])[F:1])[CH:9]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:7]=1)(=[O:18])[CH3:17]

参加物

反応物 2

HCID 7918Acetic Anhydride

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-

生成物 1

HCID 7236003',5'-Bis(trifluoromethyl)acetanilide収率 98%

実験手順

A solution of 3,5-bis(trifluoromethyl)aniline (1.28 g, 5 mmol, Aldrich) in acetic anhydride (5 mL) was stirred at room temperature for 12 h, then all of the solvent was removed to give 1.479 g (98%) of 1-acetamido-3,5-bis(trifluoromethyl)benzene as white needles. 1H NMR (CDCl3): δ2.229 (s, 3H); 7.589 (s, 1H); 8.048 (s, 2H).

後処理

customall of the solvent was removed

出典と根拠

ORDレコード: ord-bdccc2c142a8450f94500a2f86108427
出典データセット: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05622952

反応ノート

読み込み中…

参加物