Methylamine → HCID 70478659、化合物

反応式

C(O[C:4](=[O:19])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]2[NH:15][CH:16]=[CH:17][N:18]=2)=[CH:9][CH:8]=1)C.[CH3:20][NH2:21]>>[CH3:20][NH:21][C:4](=[O:19])[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][C:14]2[NH:18][CH:17]=[CH:16][N:15]=2)=[CH:11][CH:12]=1

参加物

反応物 2

HCID 6329Methylamine

HCID 70456159HCID 70456159、化合物

生成物 1

HCID 70478659HCID 70478659、化合物

実験手順

A solution of 4-(1-imidazolylmethyl)phenoxyacetic acid ethyl ester (1.02 g) in 33% ethanolic methylamine was allowed to stand for 24 hour. The solution was evaporated and the residue was crystallised from ethyl acetate/petrol to give N-methyl-4-(1-imidazolylmethyl)phenoxyacetamide (0.61 g), m.p. 124°-125° C. Found: C, 63.44, H, 6.21, N, 17.25. C13H15N3O2 requires: C, 63.66, H, 6.16, N, 17.13%.

後処理

customThe solution was evaporated
customthe residue was crystallised from ethyl acetate/petrol

出典と根拠

ORDレコード: ord-a8f32c973d0b48338e66cdc85b8290c5
出典データセット: uspto-grants-1984_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04448781

反応ノート

読み込み中…

参加物