化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl Oxalate → Ethyl 6-(4-chlorophenyl)-2,4-dioxo-hex-5-enoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Oxalate | HCID 7268 | — |
| 反応物 | 4-Chlorobenzalacetone | HCID 98183 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Ethyl 6-(4-chlorophenyl)-2,4-dioxo-hex-5-enoate | HCID 610034 | — |
反応手順
A solution of 4-(4-chlorophenyl)-3-buten-2-one (27.1 g) and diethyl oxalate (21.9 g) in dry diethyl ether (200 ml) was added dropwise over 15 minutes to a stirred suspension of sodium ethoxide (3.45 g of sodium dissolved in absolute ethanol and excess ethanol evaporated off) in dry diethyl ether (400 ml) cooled to 5°-10° C. by an ice bath. A yellow solid began to precipitate after 5 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04448787 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-1429ac1a6cb048f8990350222caf70f1 |
| 出典メモ | uspto-grants-1984_05 |