1-Methyl-3-phenylpropylamine → HCID 15572772、化合物

HRID 544365

反応式

HRID 544365 の反応式
[CH3:1][CH:2]([NH2:11])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[C:12]([C:14]1[CH:24]=[CH:23][CH:22]=[CH:21][C:15]=1[O:16][CH2:17][CH:18]1[O:20][CH2:19]1)#[N:13]>C(O)C>[C:12]([C:14]1[CH:24]=[CH:23][CH:22]=[CH:21][C:15]=1[O:16][CH2:17][CH:18]([OH:20])[CH2:19][NH:11][CH:2]([CH3:1])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)#[N:13]

参加物

4

反応物 2

HCID 311601-Methyl-3-phenylpropylamineHCID 126196712-(Oxiran-2-ylmethoxy)benzonitrile

生成物 1

HCID 15572772HCID 15572772、化合物収率 613.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In this example, 1.5 g of 1-methyl-3-phenylpropylamine and 1.8 g of 1-(2-cyanophenoxy)-2,3-epoxypropane are refluxed for 1.5 hours in 50 ml of99.5% ethanol. After completion of the reaction, the reaction solution is concentrated under reduced pressure. The residue is then charged on a column packed with silica gel and the elution is carried out with methanol. The main fraction of the eluate is concentrated under reduced pressure. Then, the residue is recrystallized from 200 ml of n-hexane to obtain 20 g of 1-(2-cyanophenoxy)-3-(1-methyl-3-phenylpropylamino)-2-propanol as crystals. (Yield: 62%)

後処理

  1. customAfter completion of the reaction
  2. concentrationthe reaction solution is concentrated under reduced pressure
  3. additionThe residue is then charged on a column
  4. washthe elution
  5. concentrationThe main fraction of the eluate is concentrated under reduced pressure
  6. customThen, the residue is recrystallized from 200 ml of n-hexane

出典と根拠

ORDレコード
ord-7981143449d14842a9c2a0b52c177a09
出典データセット
uspto-grants-1984_05
特許番号
US04450115

関連ノート

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