化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → 19-Iodononadecanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Tosylchloramide | HCID 31388 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 18-Nonadecenoic acid | HCID 543857 | — |
| 反応物 | CID 15879360 | HCID 15879360 | — |
| 生成物 | 19-Iodononadecanoic acid | HCID 12708928 | — |
反応手順
18-Nonadecenoic acid (100 mg, 0.34 mmol) was hydroborated with dicylohexylborane (0.7 mmol) at 0° C. The organoborane was iodinated with sodium aceate (0.7 mmol), sodium iodide (0.35 mmol), and chloramine-T (0.7 mmol). The product was isolated by column chromotography on silica gel (10% ethyl acetate:hexane):yield 129 mg (89%); m/e=424.5 (calcd 424.5); NMR (CDCl3) 1.2 δ (s, 30H, alkane), 2.1 (m, 4H, --CH2CO2H--CH2I), 3.0 (t, 2H, --CH2I), 11.9 (s, 1H, --CO2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04450149 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-7f437dc3c7ac458a9838b3370473fb23 |
| 出典メモ | uspto-grants-1984_05 |