化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → 22-iododocosanoic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Tosylchloramide | HCID 31388 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 21-Docosenoic acid | HCID 4434004 | — |
| 反応物 | CID 15879360 | HCID 15879360 | — |
| 生成物 | 22-iododocosanoic Acid | HCID 9876391 | — |
反応手順
21-Docosenoic acid (55mg. 0.16 mmol) was hydroborated with dicyclohexylborane (0.32 mmol) at 0° C. The organoborane was iodinated with a mixture of sodium aceate (0.32 mmol), sodium iodide (0.16 mmol), and chloramine-T (0.32 mmol). The product was isolated by a column chromotography on silica gel (10% ethyl acetate:hexane):yield 68 mg (91%); mp 71°-2° C.; m/e 466.5 (calcd 466.5); NMR (CDCl3), 1.2 δ (s, 36H, alkane), 2.1 (m, 4H, --CH2 --CO2H and --CH2CH2I), 3.0 (t, 2H, --CH2I, 11.9 (s, 1H, --CO2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04450149 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-e824cab9876c419ea204dc475ae04813 |
| 出典メモ | uspto-grants-1984_05 |