Hydrochloric Acid → (2-Benzylthiazol-4-yl)methanol

HRID 544425ノート

反応式

HRID 544425 の反応式
[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([C:13](OCC)=[O:14])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.CCOCC.O>C1(C)C=CC=CC=1>[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([CH2:13][OH:14])[N:12]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3283Diethyl EtherHCID 1491568Ethyl 2-benzylthiazole-4-carboxylate

生成物 1

HCID 13102618(2-Benzylthiazol-4-yl)methanol収率 81.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
-5 °C

実験手順

90 ml of a toluene solution of 2 M/liter of diethyl sodium aluminum dihydride was added dropwise at -10° C. to a solution of 20 g of the product of Step A in 100 ml of toluene and the mixture was stirred at -5° C. for one hour. 150 ml of aqueous 2N hydrochloric acid were added dropwise to the mixture at -20° C. and then ether and water were added thereto. The mixture was filtered and the organic phase of the filtrate was washed with water, dried and evaporated to dryness. The residue was chromatographed over silica gel and was eluted with a 7-3 methylene chloride-ethyl acetate mixture to obtain 13.6 g of (2-benzyl-4-thiazolyl)-methanol melting about 50° C.

後処理

  1. filtrationThe mixture was filtered
  2. washthe organic phase of the filtrate was washed with water
  3. customdried
  4. customevaporated to dryness
  5. customThe residue was chromatographed over silica gel
  6. washwas eluted with a 7-3 methylene chloride-ethyl acetate mixture

出典と根拠

ORDレコード
ord-17a43a4823164f4ca437ef362210763f
出典データセット
uspto-grants-1984_05
特許番号
US04450169

反応ノート

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