Phosphorus oxychloride → 3-Chloromethyl-8-(2-fluorobenzyloxy)-2-methylimidazo[1,2-a]pyridine

HRID 544458ノート

反応式

HRID 544458 の反応式
[F:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][O:5][C:6]1[C:7]2[N:8]([C:12]([CH2:16]O)=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1.P(Cl)(Cl)([Cl:24])=O>>[Cl:24][CH2:16][C:12]1[N:8]2[CH:9]=[CH:10][CH:11]=[C:6]([O:5][CH2:4][C:3]3[CH:18]=[CH:19][CH:20]=[CH:21][C:2]=3[F:1])[C:7]2=[N:14][C:13]=1[CH3:15]

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 20458963HCID 20458963、化合物

生成物 1

HCID 204589533-Chloromethyl-8-(2-fluorobenzyloxy)-2-methylimidazo[1,2-a]pyridine

実験手順

A mixture of 8-(2-fluorobenzyloxy)3-hydroxymethyl-2-methyl-imidazo[1,2-a]pyridine from Example 5 (1 g) and phosphorylchloride (15 ml) was heated under reflux for1 hr. Excess phosphorylchloride was distilled off in vacuo, the residue dissolved in hot ethanolic HCL and the mixture filtered to give the title compound as the hydrochloride salt.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for1 hr
  3. distillationExcess phosphorylchloride was distilled off in vacuo
  4. dissolutionthe residue dissolved in hot ethanolic HCL
  5. filtrationthe mixture filtered

出典と根拠

ORDレコード
ord-897ce9cb6cf94f23b5992075724e1d19
出典データセット
uspto-grants-1984_05
特許番号
US04450164

反応ノート

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