Phosphorus oxychloride → 8-(Benzyloxy)-2-(chloromethyl)imidazo[1,2-a]pyridine

HRID 544459ノート

反応式

HRID 544459 の反応式
[CH2:1]([O:8][C:9]1[C:10]2[N:11]([CH:15]=[C:16]([CH2:18]O)[N:17]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:22])=O>>[CH2:1]([O:8][C:9]1[C:10]2[N:11]([CH:15]=[C:16]([CH2:18][Cl:22])[N:17]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 20458946[8-(Benzyloxy)imidazo[1,2-a]pyridin-2-yl]methanol

生成物 1

HCID 204590038-(Benzyloxy)-2-(chloromethyl)imidazo[1,2-a]pyridine

実験手順

A mixture of 8-benzyloxy-2-hydroxymethylimidazo[1,2-a]pyridine (2 g) and phosphorylchloride (10 ml) was heated on a steam bath for 1 hr. Excess phosphoryl chloride was distilled off in vacuo, the solid residue triturated with acetonitrile and the mixture filtered to give the title product as the hydrochloride salt.

後処理

  1. temperaturewas heated on a steam bath for 1 hr
  2. distillationExcess phosphoryl chloride was distilled off in vacuo
  3. customthe solid residue triturated with acetonitrile
  4. filtrationthe mixture filtered

出典と根拠

ORDレコード
ord-ae148568f6294f2fbb8f6fff8a9ff9cb
出典データセット
uspto-grants-1984_05
特許番号
US04450164

反応ノート

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