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Bromobenzene → 2-Methyl-8-phenoxyimidazo[1,2-a]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromobenzene | HCID 7961 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-Methylimidazo[1,2-a]pyridin-8-ol | HCID 820953 | — |
| 触媒 | Copper | HCID 23978 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 2-Methyl-8-phenoxyimidazo[1,2-a]pyridine | HCID 13900295 | — |
反応手順
A mixture of 8-hydroxy-2-methylimidazo[1,2-a]pyridine (14.8 g), bromobenzene (15.7 g), copper powder (1.0 g) and powdered potassium hydroxide (5.6 g) in N-methyl pyrrolidone was heated under reflux for 4 hrs. The solvent was removed by distillation and the residue suspended in dichloromethane, washed with 10% sodium hydroxide solution and the dichloromethane was evaporated to give 2-methyl-8-phenoxyimidazo[1,2-a]pyridine. Treatment of this compound in accordance with Examples 10 and 11 yields the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04450164 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-4500b211716041029ecd860fcd4d5549 |
| 出典メモ | uspto-grants-1984_05 |