1,3-Dichloro-2-isothiocyanatobenzene → N-(2,6-Dichlorophenyl)-4-(pyrazin-2-yl)piperazine-1-carbothioamide

HRID 544484ノート

反応式

HRID 544484 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=1[N:21]=[C:22]=[S:23]>CCOCC>[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=1[NH:21][C:22]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:23]

参加物

4

反応物 2

HCID 1232391,3-Dichloro-2-isothiocyanatobenzeneHCID 27346391-Piperazinylpyrazine

生成物 1

HCID 20459211N-(2,6-Dichlorophenyl)-4-(pyrazin-2-yl)piperazine-1-carbothioamide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added dropwise a solution of 6.12 g. of 2,6-dichlorophenyl isothiocyanate in 50 ml. of anhydrous ether over 10 minutes. The mixture is stirred for 15 minutes and the resulting solid collected. This solid is dissolved with heat in a mixture of 200 ml. of acetone and 150 ml. of methanol and then cooled. The resulting solid is collected giving 5.29 g. of the desired product as white crystals, m.p. 225°-227° C.

後処理

  1. customthe resulting solid collected
  2. dissolutionThis solid is dissolved
  3. temperaturewith heat in a mixture of 200 ml
  4. temperatureof methanol and then cooled
  5. customThe resulting solid is collected
  6. customgiving 5.29 g

出典と根拠

ORDレコード
ord-6db896f2eea74c95ac7c2c0125c4e4f9
出典データセット
uspto-grants-1984_05
特許番号
US04450272

反応ノート

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