Quipazine → N-Ethyl-4-(quinolin-2-yl)piperazine-1-carbothioamide

HRID 544488ノート

反応式

HRID 544488 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[CH2:17]([N:19]=[C:20]=[S:21])[CH3:18]>CCOCC>[CH2:17]([NH:19][C:20]([N:14]1[CH2:15][CH2:16][N:11]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)[CH2:12][CH2:13]1)=[S:21])[CH3:18]

参加物

4

反応物 2

HCID 5011QuipazineHCID 10966Ethyl isothiocyanate

生成物 1

HCID 13318697N-Ethyl-4-(quinolin-2-yl)piperazine-1-carbothioamide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a slurry of 4.26 g. of 1-(2-quinolinyl)piperazine in 30 ml. of anhydrousether is added dropwise a solution of 1.74 g. of ethyl isothiocyanate in 30ml. of anhydrous ether. The mixture is stirred for one hour and the resulting solid is collected and recrystallized from 150 ml. of ethanol, giving 4.43 g. of the desired product as a white crystalline solid, m.p. 193°-195° C.

後処理

  1. additionof anhydrousether is added dropwise a solution of 1.74 g
  2. customthe resulting solid is collected
  3. customrecrystallized from 150 ml
  4. customof ethanol, giving 4.43 g

出典と根拠

ORDレコード
ord-326458202523403b945fdb1e247f5272
出典データセット
uspto-grants-1984_05
特許番号
US04450272

反応ノート

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