2-Fluorophenyl isothiocyanate → 2'-Fluoro-4-(2-pyrazinyl)-1-piperazinethiocarboxanilide

HRID 544490

反応式

HRID 544490 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]=[C:21]=[S:22]>CCOCC>[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:22]

参加物

4

反応物 2

HCID 975202-Fluorophenyl isothiocyanateHCID 27346391-Piperazinylpyrazine

生成物 1

HCID 133186942'-Fluoro-4-(2-pyrazinyl)-1-piperazinethiocarboxanilide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added a solution of 4.59 g. of 2-fluorophenyl isothiocyanate in 50 ml. of anhydrous ether over a period of 10 minutes. The mixture is stirred for 30 minutes and the resulting solid is collectedand then recrystallized from 200 ml. of ethanol, giving 7.04 g. of the desired product, m.p. 151°-153° C.

後処理

  1. customthen recrystallized from 200 ml
  2. customof ethanol, giving 7.04 g

出典と根拠

ORDレコード
ord-b8ccbe605ef04daf82a06593a3331c0c
出典データセット
uspto-grants-1984_05
特許番号
US04450272

関連ノート

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