tert-Butyl isothiocyanate → N-tert-Butyl-4-(pyrazin-2-yl)piperazine-1-carbothioamide
反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[C:13]([N:17]=[C:18]=[S:19])([CH3:16])([CH3:15])[CH3:14]>CCOCC>[C:13]([NH:17][C:18]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:19])([CH3:16])([CH3:15])[CH3:14]参加物
4
実験手順
To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added a solution of 3.45 g. of tert-butyl isothiocyanate in 50 ml. of anhydrous ether. The mixture is stirred for 30minutes and the resulting solid is collected and recrystallized from 50 ml.of ethanol, giving 5.85 g. of the desired product as white crystals, m.p. 153°-156° C.
後処理
- customthe resulting solid is collected
- customrecrystallized from 50 ml
- customof ethanol, giving 5.85 g
出典と根拠
- ORDレコード
- ord-a597b8511d76413fa3f7b9154a995282
- 出典データセット
- uspto-grants-1984_05
- 特許番号
- US04450272
反応ノート
読み込み中…