Hydrochloric Acid → Ethanol DMPE

反応式

[Cl-].[Na+].[CH3:3][P:4]([CH2:6][CH2:7][P:8]([CH3:10])[CH3:9])[CH3:5].Cl.[CH2:12]([OH:14])[CH3:13]>>[CH2:12]([OH:14])[CH3:13].[CH3:3][P:4]([CH2:6][CH2:7][P:8]([CH3:10])[CH3:9])[CH3:5]

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 702Ethanol2 回

HCID 5234Sodium Chloride2 回

HCID 1410591,2-Bis(dimethylphosphino)ethane

生成物 1

HCID 131713514Ethanol DMPE収率 80%

実験手順

Prepare a saturated solution of sodium chloride in ethanol by dissolving 117 mg of sodium chloride in 20 ml of degassed ethanol. Add 11.1 μl of liquid DMPE to this solution and adjust its pH to approximately 2.25 by adding concentrated hydrochloric acid. Dispense 5 ml into a 10 cc vial and crimp seal it using a teflon-coated stopper. Inject approximately 5 mCi of 99mTc-pertechnetate eluate into the vial and place it in a boiling water bath for 1 hour. HPLC analysis shows a yield of greater than 80% of the [99mTcCl2 (DMPE)2 ]+ complex.