Methanol → 2-Oxo-4,6-dipropyl-1,2-dihydropyridine-3-carbonitrile

HRID 544550

反応式

HRID 544550 の反応式
[CH3:1][CH2:2][CH2:3][C:4](=O)[CH2:5][C:6](=O)[CH2:7][CH2:8][CH3:9].CO.[C:14]([CH2:16][C:17]([NH2:19])=[O:18])#[N:15].C[O-].[Na+]>O.C(O)(=O)C>[C:14]([C:16]1[C:17](=[O:18])[NH:19][C:6]([CH2:7][CH2:8][CH3:9])=[CH:5][C:4]=1[CH2:3][CH2:2][CH3:1])#[N:15]

参加物

7

反応物 4

HCID 887MethanolHCID 7898CyanoacetamideHCID 264544,6-NonanedioneHCID 10942334Sodium Methoxide

生成物 1

HCID 132990072-Oxo-4,6-dipropyl-1,2-dihydropyridine-3-carbonitrile収率 81.9%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

3-Cyano-4,6-di-n-propyl-2(1H)-pyridinone was prepared as follows: A mixture containing 15.6 g of 4,6-nonanedione, 200 ml of methanol, 10 g of cyanoacetamide and 6 g of sodium methoxide was refluxed with stirring for 22 hours and then stripped to dryness in vacuo. The residue was dissolved in 100 ml of water and the solution acidified with acetic acid. The white precipitate was collected, washed with water, air-dried, recrystallized from isopropyl alcohol-n-hexane and dried in vacuo at 80°-85° C. to produce 16.7 g of 3-cyano-4,6-di-n-propyl-2(1H)-pyridinone, m.p. 151°-152° C.

後処理

  1. custom3-Cyano-4,6-di-n-propyl-2(1H)-pyridinone was prepared
  2. temperaturewas refluxed
  3. customThe white precipitate was collected
  4. washwashed with water
  5. customair-dried
  6. customrecrystallized from isopropyl alcohol-n-hexane
  7. customdried in vacuo at 80°-85° C.

出典と根拠

ORDレコード
ord-df17b0cc4947456784a3aa58265e2ed9
出典データセット
uspto-grants-1984_05
特許番号
US04451469

関連ノート

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