Acetic Acid → 5-[7-(4-Carboxyphenoxy)heptyl]-3-methylisoxazole

HRID 544610ノート

反応式

HRID 544610 の反応式
C(C1[CH:22]=[CH:21][C:6]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[O:19][N:18]=[C:17]([CH3:20])[CH:16]=2)=[CH:5][CH:4]=1)#N.Cl.[C:24]([OH:27])(=[O:26])[CH3:25]>O>[C:24]([C:25]1[CH:22]=[CH:21][C:6]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[O:19][N:18]=[C:17]([CH3:20])[CH:16]=2)=[CH:5][CH:4]=1)([OH:27])=[O:26]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 52712085-[7-(4-Cyanophenoxy)heptyl]-3-methylisoxazole

生成物 1

HCID 52712095-[7-(4-Carboxyphenoxy)heptyl]-3-methylisoxazole

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 3.0 g (0.01 mole) of 5-[7-(4-cyanophenoxy)heptyl]-3-methylisoxazole (Example 5), 20 ml of 20% aqueous hydrochloric acid and 20 ml of glacial acetic acid was heated at reflux for 19 hours. The reaction mixture was cooled, 20 ml of water added, and the solid product collected by filtration to give 3.0 g of 5-[7-(4-carboxyphenoxy)heptyl]-3-methylisoxazole as a colorless solid, m.p. 129°-130° C.; MIC vs. rhinovirus Type 2 in vitro=10 μg/ml.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 19 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe solid product collected by filtration

出典と根拠

ORDレコード
ord-707ade732cdf4e6d862277323e126b53
出典データセット
uspto-grants-1984_05
特許番号
US04451476

反応ノート

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