4-Isopropylaniline → 4-Isopropylphenyl cyanamide
反応式
[N:1]#[C:2]Br.[CH:4]([C:7]1[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=1)([CH3:6])[CH3:5]>C(OCC)C>[CH:4]([C:7]1[CH:13]=[CH:12][C:10]([NH:11][C:2]#[N:1])=[CH:9][CH:8]=1)([CH3:6])[CH3:5]参加物
4
実験手順
A solution of cyanogen bromide (1.59 g, 15 mmol) in diethylether (20) was added dropwise to a solution of 4-isopropylaniline (3.24 g) in diethylether (50 mL) at 4° C. with stirring. After the addition, the reaction mixture was kept stirring at room temperature for 18 h. Then a solution with white precipitates formed and the precipitates were removed by filtration. The etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine, dried over MgSO4, filtered, concentrated, and dried under vacuum to yield 4-isopropylphenyl cyanamide (2.0 g, 84%).
後処理
- additionAfter the addition
- stirringthe reaction mixture was kept stirring at room temperature for 18 h
- customThen a solution with white precipitates
- customformed
- customthe precipitates were removed by filtration
- washThe etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-d8ec55e141424ed1a7ead9eed3a444d6
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05622968
反応ノート
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