化工社化工社 化学情報印刷レポート · 研究参考用
4-Methyl-3-nitroanisole → 5-Methoxy-o-toluidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methyl-3-nitroanisole | HCID 87137 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-Methoxy-o-toluidine | HCID 99500 | — |
反応手順
12.4 g of palladium-on-carbon are added to a solution of 132.9 g (0.759 mole) of 4-methyl-3-nitro-anisole in 1.1 liters of methanol and hydrogenation is carried out at room temperature. The catalyst is filtered off and the filtrate is concentrated in a vacuum rotary evaporator. Recrystallisation from isopropanol/water yields 3-amino-4-methylanisole having a melting point of 43°-44°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04451462 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-6c3bae7188a248158e890e52b408fc42 |
| 出典メモ | uspto-grants-1984_05 |