Methanethiol → 1-[5-(Methylsulfanyl)-4-nitrothiophen-2-yl]ethan-1-one
反応式
[CH3:1][SH:2].Cl[C:4]1[S:5][C:6]([C:12](=[O:14])[CH3:13])=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].O>C(O)C>[CH3:1][S:2][C:4]1[S:5][C:6]([C:12](=[O:14])[CH3:13])=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10]参加物
5
実験手順
Liquid methylmercaptan (4 ml) was added to a solution of 0.82 g of Na in 50 ml of absolute ethanol. The resulting solution was added to a solution of 7.2 g of 2-chloro-3-nitro-5-acetylthiophene in 200 ml of absolute ethanol in 15 minutes at 5° C. After stirring at room temperature for 30 minutes, 100 ml of water was added, after which the precipitate was sucked off and washed successively with water and isopropanol. The precipitate was boiled a moment with 300 ml of carbontetrachloride, cooled down, and sucked off. After drying the title compound was obtained in a yield of 6.4 g; m.p. 191°-193° C.
後処理
- washwashed successively with water and isopropanol
- temperaturecooled down
- dry with materialAfter drying the title compound
- customwas obtained in a yield of 6.4 g
出典と根拠
- ORDレコード
- ord-ecb85c68df1b4eb9a34bd7c29ea0387b
- 出典データセット
- uspto-grants-1984_05
- 特許番号
- US04451660
反応ノート
読み込み中…