化工社化工社 化学情報印刷レポート · 研究参考用
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 7-[3-[4-(Aminomethyl)phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro--1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| 反応物 | 1,1-Dimethylethyl[[4-(3-pyrrolidinyl)phenyl]methyl]carbamate | HCID 86746986 | — |
| 生成物 | 7-[3-[4-(Aminomethyl)phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro--1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 15288430 | — |
反応手順
Starting from 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.88 g, 3.3 mmol) and 1,1-dimethylethyl[[4-(3-pyrrolidinyl)-phenyl]methyl]carbamate, a procedure analogous to that given in Example 6 provided the title compound (1.02 g) as a bright yellow solid, mp 268°-272° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05622966 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-ee8762884d1541a99aa2de0ba050836d |
| 出典メモ | uspto-grants-1997_04 |