N-(1,1-Dimethylethyl)benzenemethanamine → HCID 20458608、化合物

HRID 544751

反応式

HRID 544751 の反応式
C(NC(OC1C=C(C(=O)C[Br:21])C=C(OC(=O)NCC)C=1)=O)C.[CH2:23]([NH:30][C:31]([CH3:34])([CH3:33])[CH3:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC(C)=O>[BrH:21].[CH2:23]([NH:30][C:31]([CH3:34])([CH3:33])[CH3:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

4

反応物 2

HCID 76908N-(1,1-Dimethylethyl)benzenemethanamineHCID 20458601HCID 20458601、化合物

生成物 1

HCID 20458608HCID 20458608、化合物収率 78.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 8.0 g of 3',5'-bis-(N-ethylcarbamoyloxy)-2-bromo acetophenone in 100 ml of acetone was added 7.0 g of N-benzyl-t-butylamine. The mixture was refluxed for 18 hours. The 4.1 g of N-benzyl-t-butylamine hydrobromide formed and precipitated during the reaction was filtered off and the filtrate was acidified with conc. HCl. The filtrate was now evaporated to dryness and the title compound was isolated by column chromatography on Silica gel 60 using (1) CHCl3 /ethanol (2:1), (2) ethanol as eluants. The title compound was eluted in the ethanol fraction and recrystallized from ethanol/diethylether. The identity of the product was confirmed with NMR.

後処理

  1. temperatureThe mixture was refluxed for 18 hours

出典と根拠

ORDレコード
ord-7fe92459100740a0b008c2a568a04930
出典データセット
uspto-grants-1984_05
特許番号
US04451663

関連ノート

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