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1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[3-[4-[(methylamino) methyl]phenyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| 反応物 | N-methyl-4-(3-pyrrolidinyl)benzenemethanamine | HCID 15288435 | — |
| 生成物 | 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[3-[4-[(methylamino) methyl]phenyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid | HCID 15288436 | 85% |
反応手順
Starting from 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.80 g, 3.0 mmol) and N-methyl-4-(3-pyrrolidinyl)benzene-methanamine, a procedure analogous to that given in Example 1 provided the title compound (1.11 g, 85%) as an off-white solid, mp 235°-237° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05622966 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-1852f2c77e5740aab35b1c6110db6dc1 |
| 出典メモ | uspto-grants-1997_04 |