1,2-Dimethylindole → 4-(1,2-Dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid

HRID 544780

反応式

HRID 544780 の反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[CH3:11].[Cl:12][C:13]1=[C:14]([Cl:20])[C:15]([O:17][C:18]1=[O:19])=[O:16]>C(Cl)CCl>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:15](=[O:16])[C:14]([Cl:20])=[C:13]([Cl:12])[C:18]([OH:19])=[O:17])=[C:3]1[CH3:11]

参加物

4

反応物 2

HCID 134081,2-DimethylindoleHCID 70728Dichloromaleic anhydride

生成物 1

HCID 2362024-(1,2-Dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid収率 91.5%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

A mixture of 10.0 g (0.07 mole) of 1,2-dimethylindole, 12.0 g (0.07 mole) of dichloromaleic anhydride and 200 ml of ethylene dichloride was stirred at ambient temperature for approximately eighteen hours. The solid present in the reaction mixture was collected by filtration. After drying at 60° C. in vacuo there was obtained 20.0 g of 4-(1,2-dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid (Formula VIII: R=R1 =CH3 ; Y=H) as a pale blue solid which melted over the range 150° to 153° C. Infrared spectral analysis showed a maximum at 1712 (C=O; s) cm-1.

後処理

  1. filtrationThe solid present in the reaction mixture was collected by filtration
  2. customAfter drying at 60° C. in vacuo

出典と根拠

ORDレコード
ord-5761f6fb13444cb091e56c9747bc6043
出典データセット
uspto-grants-1984_05
特許番号
US04451657

関連ノート

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