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3-(Pyrrolidin-3-yl)pyridine → 1-Cyclopropyl 6-fluoro-1,4-dihydro-4-oxo-7-[3-(3-pyridinyl)-1-pyrrolidinyl]-3-quinolinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Pyrrolidin-3-yl)pyridine | HCID 3613651 | — |
| 反応物 | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| 生成物 | 1-Cyclopropyl 6-fluoro-1,4-dihydro-4-oxo-7-[3-(3-pyridinyl)-1-pyrrolidinyl]-3-quinolinecarboxylic acid | HCID 15230326 | 73% |
反応手順
Starting from 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (1.06 g, 4.0 mmol) and 3-(3-pyrrolidinyl) pyridine, a procedure analogous to that given in Example 1 provided the title compound (1.15 g, 73%) as an off-white solid, mp 233°-236° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05622966 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-44a6a19662bb40f18d86340a98b3e672 |
| 出典メモ | uspto-grants-1997_04 |