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HRID 544947作成日：2026年10月26日

3-Bromo-4-methylpyridine → N-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-5-(4-methylpyridin-3-yl)thiophene-2-carboxamide

https://huagongshe.com/reaction/544947

反応式

関与物質

役割名称HCID仕込み量
反応物3-Bromo-4-methylpyridineHCID 817630—
反応物5-(5-(Cyclopropylcarbamoyl)-2-methylphenylcarbamoyl)thiophen-2-ylboronic acidHCID 59761503—
生成物N-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-5-(4-methylpyridin-3-yl)thiophene-2-carboxamideHCID 59761479—

反応手順

The title compound was prepared by coupling 5-(5-(cyclopropylcarbamoyl)-2-methylphenylcarbamoyl)thiophen-2-ylboronic acid (Example 210, Step A) with commercially available 3-bromo-4-methylpyridine using the method described in Step B of Example 136 to afford a white solid after purification by reverse phase preparative HPLC (Example 212). HPLC Ret time=1.99 min. LCMS [M+H]+ 392.3.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07935696B2
出典データセットuspto-grants-2011_05
ORD IDord-c5af1b031a43493c857b16b01bb5475d
出典メモuspto-grants-2011_05