Sodium Bicarbonate → (S)-Benzyl piperidine-2-carboxylate

HRID 54497

反応式

HRID 54497 の反応式
[NH:1]1[CH2:16][CH2:15][CH2:14][CH2:13][CH:2]1[C:3]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:4].C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[NH:1]1[CH2:16][CH2:15][CH2:14][CH2:13][C@H:2]1[C:3]([O:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)=[O:4]

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 12436232Benzyl piperidine-2-carboxylate

生成物 1

HCID 12436231(S)-Benzyl piperidine-2-carboxylate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Benzyl pipecolate was routinely generated by treating an ethyl acetate suspension of this salt with saturated sodium bicarbonate until dissolution of the organic material. The aqueous layer was extracted twice with ethyl acetate and the combined organic extracts were dried with MgSO4 and evaporated to yield (S)-Benzyl pipecolate (15) as a pale yellow oil.

後処理

  1. additionby treating
  2. dissolutionuntil dissolution of the organic material
  3. extractionThe aqueous layer was extracted twice with ethyl acetate
  4. dry with materialthe combined organic extracts were dried with MgSO4
  5. customevaporated

出典と根拠

ORDレコード
ord-f218f10babd54387b3ff407e2cd3e023
出典データセット
uspto-grants-1997_04
特許番号
US05622970

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