2-Chloro-3-(trifluoromethyl)pyridine → 2-Methoxy-3-(trifluoromethyl)pyridine

HRID 545068ノート

反応式

HRID 545068 の反応式
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O-:13].[Na+]>CO>[CH3:12][O:13][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 10942334Sodium Methoxide

生成物 1

HCID 27753092-Methoxy-3-(trifluoromethyl)pyridine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Heat a mixture of 2-chloro-3-trifluoromethyl-pyridine (1.8 g, 10 mmol) and sodium methoxide (4M, 5 mL, 20 mmol) in MeOH (20 mL) at reflux for 18 hours. Cool the mixture and remove the volatiles by rotary evaporation. Dissolve the residue in EtOAc (50 mL) and wash with water (50 mL), saturated NaHCO3(aq) (50 mL) and brine (50 mL). Dry the organic extract over MgSO4 and remove the solvent under reduced pressure to yield the title compound.

後処理

  1. temperatureHeat
  2. temperatureat reflux for 18 hours
  3. temperatureCool the mixture
  4. customremove the volatiles
  5. customby rotary evaporation
  6. dissolutionDissolve the residue in EtOAc (50 mL)
  7. washwash with water (50 mL), saturated NaHCO3(aq) (50 mL) and brine (50 mL)
  8. customDry the
  9. extractionorganic extract over MgSO4
  10. customremove the solvent under reduced pressure

出典と根拠

ORDレコード
ord-7dceeb3bdea34bc9b81ebf9dac1ee8d5
出典データセット
uspto-grants-2011_05
特許番号
US07935702B2

反応ノート

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