Ethyl bromopyruvate → HCID 178470113、化合物

HRID 545105ノート

反応式

HRID 545105 の反応式
Br[CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:10](=[S:13])([S-:12])[NH2:11].[NH4+]>C(O)C>[CH2:7]([O:6][C:4]([C:3]1[N:11]=[C:10]([SH:13])[S:12][CH:2]=1)=[O:5])[CH3:8]

参加物

4

反応物 2

HCID 66144Ethyl bromopyruvateHCID 11083854Ammonium dithiocarbamate

生成物 1

HCID 178470113HCID 178470113、化合物収率 65.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl bromopyruvate (90%, 100 g) was completely dissolved in ethanol (1000 mL), ammonium dithiocarbamate (55.9 g) was added, and the mixture was stirred at room temperature for 2.5 hrs and heated under reflux for 1 hr. After completion of the reaction, the solvent was evaporated under reduced pressure, water was added to the obtained residue. The solid was collected by filtration, washed with water and isopropyl ether, and dried to give the title compound (63.3 g) as a yellow powder.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 1 hr
  3. customAfter completion of the reaction
  4. customthe solvent was evaporated under reduced pressure, water
  5. additionwas added to the obtained residue
  6. filtrationThe solid was collected by filtration
  7. washwashed with water and isopropyl ether
  8. customdried

出典と根拠

ORDレコード
ord-e1e5dc99a7c84d74bd109e9411a8dee4
出典データセット
uspto-grants-2011_05
特許番号
US07935700B2

反応ノート

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